Human hepatic metabolism of the anti-osteoporosis drug eldecalcitol involves sterol C4-methyl oxidase

The metabolism of eldecalcitol (ED-71), a 2β-hydroxypropoxylated analog of the active form of vitamin D(3) was investigated by using in vitro systems. ED-71 was metabolized to 1α,2β,25-trihydroxyvitamin D(3) (1α,2β,25(OH)(3)D(3)) in human small intestine and liver microsomes. To identify the enzymes...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Yasuda, Kaori, Iwanaga, Yuasa, Ogawa, Kazuaki, Mano, Hiroki, Ueno, Sera, Kimoto, Shutaro, Ohta, Miho, Kamakura, Masaki, Ikushiro, Shinichi, Sakaki, Toshiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448988/
https://ncbi.nlm.nih.gov/pubmed/26038696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.120
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