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Computational predictions of substituted benzyne and indolyne regioselectivities

A computational study using DFT methods was performed for an array of mono and disubstituted benzynes and indolynes. The inherent distortion present in the geometry-optimized structures predicts the regioselectivity of aryne trapping by nucleophiles or cycloaddition partners. These studies will serv...

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Bibliografiska uppgifter
I publikationen:Tetrahedron Lett
Huvudupphovsmän: Picazo, Elias, Houk, K. N., Garg, Neil K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448725/
https://ncbi.nlm.nih.gov/pubmed/26034336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2015.01.022
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