Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport

Bcl-2 family proteins are key regulators for cellular homeostasis in response to apoptotic stimuli. Bcl-xL, an antiapoptotic Bcl-2 family member, undergoes conformational transitions, which leads to two conformational states: the cytoplasmic and membrane-bound. Here we present the crystal and small-...

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Publicat a:Sci Rep
Autors principals: Rajan, Sreekanth, Choi, Minjoo, Nguyen, Quoc Toan, Ye, Hong, Liu, Wei, Toh, Hui Ting, Kang, CongBao, Kamariah, Neelagandan, Li, Chi, Huang, Huiya, White, Carl, Baek, Kwanghee, Grüber, Gerhard, Yoon, Ho Sup
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448555/
https://ncbi.nlm.nih.gov/pubmed/26023881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10609
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