The N Terminus of Sarcolipin Plays an Important Role in Uncoupling Sarco-endoplasmic Reticulum Ca(2+)-ATPase (SERCA) ATP Hydrolysis from Ca(2+) Transport

The sarcoendoplasmic reticulum Ca(2+)-ATPase (SERCA) is responsible for intracellular Ca(2+) homeostasis. SERCA activity in muscle can be regulated by phospholamban (PLB), an affinity modulator, and sarcolipin (SLN), an uncoupler. Although PLB gets dislodged from Ca(2+)-bound SERCA, SLN continues to...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sahoo, Sanjaya K., Shaikh, Sana A., Sopariwala, Danesh H., Bal, Naresh C., Bruhn, Dennis Skjøth, Kopec, Wojciech, Khandelia, Himanshu, Periasamy, Muthu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447977/
https://ncbi.nlm.nih.gov/pubmed/25882845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.636738
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