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Transcriptional Dysregulation of γ-Aminobutyric Acid Transporter in Parvalbumin-Containing Inhibitory Neurons in the Prefrontal Cortex in Schizophrenia

Parvalbumin (PV)-containing neurons are functionally compromised in schizophrenia. Using double in situ hybridization in postmortem human prefrontal cortex, we found that the messenger RNA (mRNA) for the γ-aminobutyric acid transporter GAT-1 was undetectable in 22-41% of PV neurons in layers 3-4 in...

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Bibliografiske detaljer
Udgivet i:Psychiatry Res
Main Authors: Bitanihirwe, Byron K. Y., Woo, Tsung-Ung W.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447488/
https://ncbi.nlm.nih.gov/pubmed/25312391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.psychres.2014.09.016
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