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Epileptogenesis following Kainic Acid-Induced Status Epilepticus in Cyclin D2 Knock-Out Mice with Diminished Adult Neurogenesis

The goal of this study was to determine whether a substantial decrease in adult neurogenesis influences epileptogenesis evoked by the intra-amygdala injection of kainic acid (KA). Cyclin D2 knockout (cD2 KO) mice, which lack adult neurogenesis almost entirely, were used as a model. First, we examine...

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Vydáno v:PLoS One
Hlavní autoři: Kondratiuk, Ilona, Plucinska, Gabriela, Miszczuk, Diana, Wozniak, Grazyna, Szydlowska, Kinga, Kaczmarek, Leszek, Filipkowski, Robert K., Lukasiuk, Katarzyna
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447381/
https://ncbi.nlm.nih.gov/pubmed/26020770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128285
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