Signature Patterns of MHC Diversity in Three Gombe Communities of Wild Chimpanzees Reflect Fitness in Reproduction and Immune Defense against SIVcpz

Major histocompatibility complex (MHC) class I molecules determine immune responses to viral infections. These polymorphic cell-surface glycoproteins bind peptide antigens, forming ligands for cytotoxic T and natural killer cell receptors. Under pressure from rapidly evolving viruses, hominoid MHC c...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Wroblewski, Emily E., Norman, Paul J., Guethlein, Lisbeth A., Rudicell, Rebecca S., Ramirez, Miguel A., Li, Yingying, Hahn, Beatrice H., Pusey, Anne E., Parham, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447270/
https://ncbi.nlm.nih.gov/pubmed/26020813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002144
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