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Effect of Probenecid on Cerebrospinal Fluid Concentrations of Penicillin and Cephalosporin Derivatives

Probenecid may elevate the cerebrospinal fluid (CSF) concentration of penicillin G by inhibiting the excretion of organic acids from CSF. We have studied this phenomenon with various penicillin and cephalosporin derivatives. Penicillin concentrations were determined in rabbits under steady-state con...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Principais autores: Dacey, Ralph G., Sande, Merle A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1974
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC444667/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4157341/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.6.4.437
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