Lithium protects against paraquat neurotoxicity by NRF2 activation and miR-34a inhibition in SH-SY5Y cells

Lithium is a mood stabilizing agent commonly used for the treatment of bipolar disorder. Here, we investigated the potential neuroprotective effect of lithium against paraquat toxicity and its underlying mechanisms in vitro. SH-SY5Y human neuroblastoma cells were treated with paraquat (PQ) 0.5 mM co...

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Bibliographic Details
Published in:Front Cell Neurosci
Main Authors: Alural, Begum, Ozerdem, Aysegul, Allmer, Jens, Genc, Kursad, Genc, Sermin
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446540/
https://ncbi.nlm.nih.gov/pubmed/26074776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00209
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