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Molecular insights into HSD10 disease: impact of SDR5C1 mutations on the human mitochondrial RNase P complex

SDR5C1 is an amino and fatty acid dehydrogenase/reductase, moonlighting as a component of human mitochondrial RNase P, which is the enzyme removing 5′-extensions of tRNAs, an early and crucial step in tRNA maturation. Moreover, a subcomplex of mitochondrial RNase P catalyzes the N(1)-methylation of...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Vilardo, Elisa, Rossmanith, Walter
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446446/
https://ncbi.nlm.nih.gov/pubmed/25925575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv408
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