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Sequencing the cap-snatching repertoire of H1N1 influenza provides insight into the mechanism of viral transcription initiation

The influenza polymerase cleaves host RNAs ∼10–13 nucleotides downstream of their 5′ ends and uses this capped fragment to prime viral mRNA synthesis. To better understand this process of cap snatching, we used high-throughput sequencing to determine the 5′ ends of A/WSN/33 (H1N1) influenza mRNAs. T...

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Publicat a:Nucleic Acids Res
Autors principals: Koppstein, David, Ashour, Joseph, Bartel, David P.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446424/
https://ncbi.nlm.nih.gov/pubmed/25901029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv333
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