Exosome-mediated Delivery of the Intrinsic C-terminus Domain of PTEN Protects It From Proteasomal Degradation and Ablates Tumorigenesis

PTEN mutation is a frequent feature across a plethora of human cancers, the hot-spot being its C-terminus (PTEN-CT) regulatory domain resulting in a much diminished protein expression. In this study, the presence of C-terminus mutations was confirmed through sequencing of different human tumor sampl...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Ther
Egile Nagusiak: Ahmed, Syed Feroj, Das, Nilanjana, Sarkar, Moumita, Chatterjee, Uttara, Chatterjee, Sandip, Ghosh, Mrinal Kanti
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2015
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445612/
https://ncbi.nlm.nih.gov/pubmed/25327178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.202
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