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Skeletal muscle myotubes of the severely obese exhibit altered ubiquitin-proteasome and autophagic/lysosomal proteolytic flux

OBJECTIVE: Whole-body protein metabolism is dysregulated with obesity. Our goal was to determine if activity and expression of major protein degradation pathways are compromised specifically in human skeletal muscle with obesity. METHODS: We utilized primary Human Skeletal Muscle cell (HSkM) culture...

詳細記述

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書誌詳細
出版年:Obesity (Silver Spring)
主要な著者: Bollinger, Lance M., Powell, Jonathan J. S., Houmard, Joseph A., Witczak, Carol A., Brault, Jeffrey J.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445474/
https://ncbi.nlm.nih.gov/pubmed/26010327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/oby.21081
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