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Skeletal muscle myotubes of the severely obese exhibit altered ubiquitin-proteasome and autophagic/lysosomal proteolytic flux

OBJECTIVE: Whole-body protein metabolism is dysregulated with obesity. Our goal was to determine if activity and expression of major protein degradation pathways are compromised specifically in human skeletal muscle with obesity. METHODS: We utilized primary Human Skeletal Muscle cell (HSkM) culture...

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Bibliografske podrobnosti
izdano v:Obesity (Silver Spring)
Main Authors: Bollinger, Lance M., Powell, Jonathan J. S., Houmard, Joseph A., Witczak, Carol A., Brault, Jeffrey J.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445474/
https://ncbi.nlm.nih.gov/pubmed/26010327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/oby.21081
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