Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss

Leber hereditary optic neuropathy is due to mitochondrial DNA mutations; in ~70% of all cases, a point mutation in the mitochondrial NADH dehydrogenase subunit 4, ND4, gene leads to central vision loss. We optimized allotopic expression (nuclear transcription of a gene that is normally transcribed i...

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Bibliografiska uppgifter
I publikationen:Mol Ther Methods Clin Dev
Huvudupphovsmän: Cwerman-Thibault, Hélène, Augustin, Sébastien, Lechauve, Christophe, Ayache, Jessica, Ellouze, Sami, Sahel, José-Alain, Corral-Debrinski, Marisol
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4444999/
https://ncbi.nlm.nih.gov/pubmed/26029714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2015.3
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