Opioid-induced hyperalgesia in chronic pain patients and the mitigating effects of gabapentin

Chronic pain patients receiving opioid drugs are at risk for opioid-induced hyperalgesia (OIH), wherein opioid pain medication leads to a paradoxical pain state. OIH involves central sensitization of primary and secondary afferent neurons in the dorsal horn and dorsal root ganglion, similar to neuro...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Stoicea, Nicoleta, Russell, Daric, Weidner, Greg, Durda, Michael, Joseph, Nicholas C., Yu, Jeffrey, Bergese, Sergio D.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4444749/
https://ncbi.nlm.nih.gov/pubmed/26074817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00104
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