Quantifying the cumulative effect of low-penetrance genetic variants on breast cancer risk

Many common diseases have a complex genetic basis in which large numbers of genetic variations combine with environmental factors to determine risk. However, quantifying such polygenic effects has been challenging. In order to address these difficulties we developed a global measure of the informati...

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Detalles Bibliográficos
Publicado en:Mol Genet Genomic Med
Main Authors: Smyth, Conor, Špakulová, Iva, Cotton-Barratt, Owen, Rafiq, Sajjad, Tapper, William, Upstill-Goddard, Rosanna, Hopper, John L, Makalic, Enes, Schmidt, Daniel F, Kapuscinski, Miroslav, Fliege, Jörg, Collins, Andrew, Brodzki, Jacek, Eccles, Diana M, MacArthur, Ben D
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2015
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4444159/
https://ncbi.nlm.nih.gov/pubmed/26029704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mgg3.129
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