Pan-Cancer Network Analysis Identifies Combinations of Rare Somatic Mutations across Pathways and Protein Complexes

Cancers exhibit extensive mutational heterogeneity and the resulting long tail phenomenon complicates the discovery of the genes and pathways that are significantly mutated in cancer. We perform a Pan-Cancer analysis of mutated networks in 3281 samples from 12 cancer types from The Cancer Genome Atl...

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Publicado no:Nat Genet
Main Authors: Leiserson, Mark D.M., Vandin, Fabio, Wu, Hsin-Ta, Dobson, Jason R., Eldridge, Jonathan V., Thomas, Jacob L., Papoutsaki, Alexandra, Kim, Younhun, Niu, Beifang, McLellan, Michael, Lawrence, Michael S., Gonzalez-Perez, Abel, Tamborero, David, Cheng, Yuwei, Ryslik, Gregory A., Lopez-Bigas, Nuria, Getz, Gad, Ding, Li, Raphael, Benjamin J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4444046/
https://ncbi.nlm.nih.gov/pubmed/25501392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3168
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