The Dopamine Stabilizer (−)-OSU6162 Occupies a Subpopulation of Striatal Dopamine D2/D3 Receptors: An [(11)C]Raclopride PET Study in Healthy Human Subjects

(−)-OSU6162 is a dopamine stabilizer that can counteract both hyperdopaminergic and hypodopaminergic states. In this study, D2/D3 receptor occupancy of (−)-OSU6162 in the human brain was investigated using positron emission tomography (PET). Twelve male healthy volunteers underwent [(11)C]raclopride...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Tolboom, Nelleke, Berendse, Henk W, Leysen, Josee E, Yaqub, Maqsood, van Berckel, Bart NM, Schuit, Robert C, Ponsen, Mirthe M, Bakker, Esther, Hoetjes, Nikie J, Windhorst, Albert D, Carlsson, Maria L, Lammertsma, Adriaan A, Carlsson, Arvid
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443962/
https://ncbi.nlm.nih.gov/pubmed/25248987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.195
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