Platelet G(i) protein Gα(i2) is an essential mediator of thrombo-inflammatory organ damage in mice

Platelets are crucial for hemostasis and thrombosis and exacerbate tissue injury following ischemia and reperfusion. Important regulators of platelet function are G proteins controlled by seven transmembrane receptors. The G(i) protein Gα(i2) mediates platelet activation in vitro, but its in vivo ro...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Devanathan, Vasudharani, Hagedorn, Ina, Köhler, David, Pexa, Katja, Cherpokova, Deya, Kraft, Peter, Singh, Madhurendra, Rosenberger, Peter, Stoll, Guido, Birnbaumer, Lutz, Piekorz, Roland P., Beer-Hammer, Sandra, Nieswandt, Bernhard, Nürnberg, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443332/
https://ncbi.nlm.nih.gov/pubmed/25944935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505887112
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