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Combined Diazepam and MK-801 Therapy Provides Synergistic Protection from Tetramethylenedisulfotetramine-induced Tonic-Clonic Seizures and Lethality in Mice

The synthetic rodenticide, tetramethylenedisulfotetramine (TMDT), is a persistent and highly lethal GABA-gated Cl(−) channel blocker. TMDT is clandestinely produced, remains popular in mainland China, and causes numerous unintentional and deliberate poisonings worldwide. TMDT is odorless, tasteless,...

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Detalhes bibliográficos
Publicado no:Neurotoxicology
Main Authors: Shakarjian, Michael P., Ali, Mahil S., Velíšková, Jana, Stanton, Patric K., Heck, Diane E., Velíšek, Libor
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442737/
https://ncbi.nlm.nih.gov/pubmed/25783504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2015.03.007
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