Viral Bcl-2 Encoded by the Kaposi's Sarcoma-Associated Herpesvirus Is Vital for Virus Reactivation

The Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 16 (orf16) encodes a viral Bcl-2 (vBcl-2) protein which shares sequence and functional homology with the Bcl-2 family. Like its cellular homologs, vBcl-2 protects various cell types from apoptosis and can also negatively regu...

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Bibliographic Details
Published in:J Virol
Main Authors: Gelgor, Anastasia, Kalt, Inna, Bergson, Shir, Brulois, Kevin F., Jung, Jae U., Sarid, Ronit
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442508/
https://ncbi.nlm.nih.gov/pubmed/25740992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00098-15
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