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Mechanism of HIV-1 Resistance to Short-Peptide Fusion Inhibitors Targeting the Gp41 Pocket

The deep hydrophobic pocket on the N trimer of HIV-1 gp41 has been considered an ideal drug target. On the basis of the M-T hook structure, we recently developed short-peptide-based HIV-1 fusion inhibitors (MTSC22 and HP23), which mainly target the pocket site and possess highly potent antiviral act...

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Publicat a:J Virol
Autors principals: Su, Yang, Chong, Huihiui, Qiu, Zonglin, Xiong, Shengwen, He, Yuxian
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442445/
https://ncbi.nlm.nih.gov/pubmed/25787278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00373-15
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