Randomized phase 1b trial of MOR103, a human antibody to GM-CSF, in multiple sclerosis

OBJECTIVES: To determine the safety, pharmacokinetics (PK), and immunogenicity of the recombinant human monoclonal antibody MOR103 to granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with multiple sclerosis (MS) with clinical or MRI activity. METHODS: In this 20-week, randomized...

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Detalhes bibliográficos
Publicado no:Neurol Neuroimmunol Neuroinflamm
Main Authors: Constantinescu, Cris S., Asher, Aliya, Fryze, Waldemar, Kozubski, Wojciech, Wagner, Frank, Aram, Jehan, Tanasescu, Radu, Korolkiewicz, Roman P., Dirnberger-Hertweck, Maren, Steidl, Stefan, Libretto, Susan E., Sprenger, Till, Radue, Ernst W.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442097/
https://ncbi.nlm.nih.gov/pubmed/26185773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXI.0000000000000117
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