Allopurinol and 5-aminosalicylic acid influence thiopurine-induced hepatotoxicity in vitro

INTRODUCTION: The use of thiopurines is frequently accompanied by hepatotoxicity. Studies on hepatocyte cultures showed a time- and dose-dependent increase of thiopurine toxicity. 5-Aminosalicylic acid (5-ASA) and allopurinol can influence thiopurine metabolism; however, it is unknown whether this a...

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Publicado no:Cell Biol Toxicol
Main Authors: Broekman, Mark M. T. J., Roelofs, Hennie M. J., Wong, Dennis R., Kerstholt, Mariska, Leijten, Alex, Hoentjen, Frank, Peters, Wilbert H. M., Wanten, Geert J. A., de Jong, Dirk J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441745/
https://ncbi.nlm.nih.gov/pubmed/25916701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10565-015-9301-1
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