rAAV8-mediated inhibition of miRNA-21 protects mice against the lethal schistosome infection by repressing both IL-13 and TGF-β1 pathways

Schistosomiasis is a serious parasitic disease in humans, which can lead to liver fibrosis and death. Accumulating evidence indicated that targeting the deregulated microRNAs could mitigate disease outcomes. Here, we showed that progressive hepatic schistosomiasis caused elevation of miR-21 and effi...

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Dettagli Bibliografici
Pubblicato in:Hepatology
Autori principali: He, Xing, Xie, Jun, Zhang, Dongmei, Su, Qin, Sai, Xue, Bai, Ruipu, Chen, Chao, Luo, Xufeng, Gao, Guangping, Pan, Weiqing
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441614/
https://ncbi.nlm.nih.gov/pubmed/25546547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27671
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