Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines

B-cells are promising candidate autologous antigen-presenting cells (APCs) to prime antigen-specific T-cells both in vitro and in vivo. However to date, a significant barrier to utilizing B-cells as APCs is their low capacity for non-specific antigen uptake compared to “professional” APCs such as de...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Lee Szeto, Gregory, Van Egeren, Debra, Worku, Hermoon, Sharei, Armon, Alejandro, Brian, Park, Clara, Frew, Kirubel, Brefo, Mavis, Mao, Shirley, Heimann, Megan, Langer, Robert, Jensen, Klavs, Irvine, Darrell J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441198/
https://ncbi.nlm.nih.gov/pubmed/25999171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10276
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