Evaluating early administration of the hydroxymethylglutaryl-CoA reductase inhibitor simvastatin in the prevention and treatment of delirium in critically ill ventilated patients (MoDUS trial): study protocol for a randomized controlled trial

BACKGROUND: The incidence of delirium in ventilated patients is estimated at up to 82%, and it is associated with longer intensive care and hospital stays, and long-term cognitive impairment and mortality. The pathophysiology of delirium has been linked with inflammation and neuronal apoptosis. Simv...

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Detalhes bibliográficos
Publicado no:Trials
Main Authors: Casarin, Annalisa, McAuley, Daniel F, Alce, Timothy M, Zhao, Xiaobei, Ely, E Wesley, Jackson, Jim C, McDowell, Cliona, Agus, Ashley, Murphy, Lynn, Page, Valerie J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Study Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440514/
https://ncbi.nlm.nih.gov/pubmed/25982544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-015-0731-0
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