Intratumoral injection of IFN-alpha dendritic cells after dacarbazine activates anti-tumor immunity: results from a phase I trial in advanced melanoma

BACKGROUND: Advanced melanoma patients have an extremely poor long term prognosis and are in strong need of new therapies. The recently developed targeted therapies have resulted in a marked antitumor effect, but most responses are partial and some degree of toxicity remain the major concerns. Dendr...

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Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: Rozera, Carmela, Cappellini, Giancarlo Antonini, D’Agostino, Giuseppina, Santodonato, Laura, Castiello, Luciano, Urbani, Francesca, Macchia, Iole, Aricò, Eleonora, Casorelli, Ida, Sestili, Paola, Montefiore, Enrica, Monque, Domenica, Carlei, Davide, Napolitano, Mariarosaria, Rizza, Paola, Moschella, Federica, Buccione, Carla, Belli, Roberto, Proietti, Enrico, Pavan, Antonio, Marchetti, Paolo, Belardelli, Filippo, Capone, Imerio
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438625/
https://ncbi.nlm.nih.gov/pubmed/25933939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0473-5
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