Evaluation of in vivo responses of sorafenib therapy in a preclinical mouse model of PTEN-deficient of prostate cancer

BACKGROUND: Despite recent advances in the treatment for advanced prostate cancer, outcomes remain poor. This lack of efficacy has prompted the development of alternative treatment strategies. In the present study we investigate the effects of the multikinase inhibitor sorafenib in a genetically eng...

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Bibliografski detalji
Izdano u:J Transl Med
Glavni autori: Yamamoto, Yutaka, De Velasco, Marco A, Kura, Yurie, Nozawa, Masahiro, Hatanaka, Yuji, Oki, Takashi, Ozeki, Takayuki, Shimizu, Nobutaka, Minami, Takafumi, Yoshimura, Kazuhiro, Yoshikawa, Kazuhiro, Nishio, Kazuto, Uemura, Hirotsugu
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438623/
https://ncbi.nlm.nih.gov/pubmed/25953027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0509-x
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