Evaluation of in vivo responses of sorafenib therapy in a preclinical mouse model of PTEN-deficient of prostate cancer

BACKGROUND: Despite recent advances in the treatment for advanced prostate cancer, outcomes remain poor. This lack of efficacy has prompted the development of alternative treatment strategies. In the present study we investigate the effects of the multikinase inhibitor sorafenib in a genetically eng...

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Pubblicato in:J Transl Med
Autori principali: Yamamoto, Yutaka, De Velasco, Marco A, Kura, Yurie, Nozawa, Masahiro, Hatanaka, Yuji, Oki, Takashi, Ozeki, Takayuki, Shimizu, Nobutaka, Minami, Takafumi, Yoshimura, Kazuhiro, Yoshikawa, Kazuhiro, Nishio, Kazuto, Uemura, Hirotsugu
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438623/
https://ncbi.nlm.nih.gov/pubmed/25953027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0509-x
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