Associations of antibodies against citrullinated peptides with human leukocyte antigen-shared epitope and smoking prior to the development of rheumatoid arthritis

INTRODUCTION: It has previously been shown that an increased number of antibodies against citrullinated peptides/proteins (ACPA) predate the onset of rheumatoid arthritis (RA). Over time antibody positivity expands, involving more specific responses when approaching the onset of symptoms. We investi...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Kokkonen, Heidi, Brink, Mikael, Hansson, Monika, Lassen, Ewa, Mathsson-Alm, Linda, Holmdahl, Rikard, Rönnelid, Johan, Klareskog, Lars, Rantapää-Dahlqvist, Solbritt
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438519/
https://ncbi.nlm.nih.gov/pubmed/25990747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0638-x
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