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Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site

Enzymes enable life by accelerating reaction rates to biological timescales. Conventional studies have focused on identifying the residues that have a direct involvement in an enzymatic reaction, but these so-called ‘catalytic residues’ are embedded in extensive interaction networks. Although fundam...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Sunden, Fanny, Peck, Ariana, Salzman, Julia, Ressl, Susanne, Herschlag, Daniel
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438272/
https://ncbi.nlm.nih.gov/pubmed/25902402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06181
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