IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency

IFI44 is an interferon-alfa inducible protein, and is associated with infection of several viruses. However, IFI44 elicits minimal antiviral effects on these viruses, and its exact role is still unknown. Here we show that IFI44 inhibits HIV-1 replication in vitro. Through depletion of endogenous IFI...

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Publicado no:Virology
Main Authors: Power, Derek, Santoso, Netty, Dieringer, Michael, Yu, Jack, Huang, Huachao, Simpson, Sydney, Seth, Ishir, Gao, Geng, Miao, Hongyu, Elledge, Stephen, Zhu, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437885/
https://ncbi.nlm.nih.gov/pubmed/25776761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2015.02.046
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