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A randomized Phase II clinical study of combining panitumumab and bevacizumab, plus irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) compared with FOLFIRI alone as second-line treatment for patients with metastatic colorectal cancer and KRAS mutation

BACKGROUND: This study investigated the efficacy and safety of a new treatment strategy of combining panitumumab and bevacizumab, plus irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) versus FOLFIRI alone as second-line chemotherapy for metastatic colorectal cancer (mCRC) patients with known V-K...

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Detalhes bibliográficos
Publicado no:Onco Targets Ther
Main Authors: Liu, Yuguo, Luan, Lijuan, Wang, Xingli
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437615/
https://ncbi.nlm.nih.gov/pubmed/25999741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S81442
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