The mitochondrial environment is required for activity of the cholesterol side-chain cleavage enzyme, cytochrome P450scc.

Steroidogenesis is initiated by the conversion of cholesterol to pregnenolone by mitochondrial cytochrome P450scc [cholesterol, reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving); EC 1.14.15.6]. Several subsequent steroidal conversions occur in the endoplasmic reticulum (ER), but...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Black, S M, Harikrishna, J A, Szklarz, G D, Miller, W L
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1994
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44376/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8041774/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.15.7247
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