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Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5(+) Stem Cells

The mammalian adult small intestinal epithelium is a rapidly self-renewing tissue that is maintained by a pool of cycling stem cells intermingled with Paneth cells at the base of crypts. These crypt base stem cells exclusively express Lgr5 and require Wnt3 or, in its absence, Wnt2b. However, the Fri...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Flanagan, Dustin J., Phesse, Toby J., Barker, Nick, Schwab, Renate H.M., Amin, Nancy, Malaterre, Jordane, Stange, Daniel E., Nowell, Cameron J., Currie, Scott A., Saw, Jarel T.S., Beuchert, Eva, Ramsay, Robert G., Sansom, Owen J., Ernst, Matthias, Clevers, Hans, Vincan, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437483/
https://ncbi.nlm.nih.gov/pubmed/25892522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.03.003
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