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Bioactive heterocycles containing endocyclic N-hydroxy groups
Drug-likeness rules consider N-O single bonds as “structural alerts” which should not be present in a perspective drug candidate. In most cases this concern is correct, since it is known that N-hydroxy metabolites of branded drugs produce reactive species that cause serious side effects. However, th...
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| Gepubliceerd in: | Eur J Med Chem |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4436092/ https://ncbi.nlm.nih.gov/pubmed/25466924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.11.031 |
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