Genetic Diversity in the Collaborative Cross Model Recapitulates Human West Nile Virus Disease Outcomes

West Nile virus (WNV) is an emerging neuroinvasive flavivirus that now causes significant morbidity and mortality worldwide. The innate and adaptive immune responses to WNV infection have been well studied in C57BL/6J inbred mice, but this model lacks the variations in susceptibility, immunity, and...

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Publicado en:mBio
Main Authors: Graham, Jessica B., Thomas, Sunil, Swarts, Jessica, McMillan, Aimee A., Ferris, Martin T., Suthar, Mehul S., Treuting, Piper M., Ireton, Renee, Gale, Michael, Lund, Jennifer M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Microbiology 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4436067/
https://ncbi.nlm.nih.gov/pubmed/25944860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00493-15
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