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Epigenetic Manipulation Restores Functions of Defective CD8(+) T Cells From Chronic Viral Infection
Functional exhaustion of antigen-specific T cells is a defining characteristic of many chronic infections, but the underlying mechanisms of T cell dysfunction are not well understood. Epigenetics plays an important role in the control of T cell development, differentiation, and function. To examine...
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| Veröffentlicht in: | Mol Ther |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4435497/ https://ncbi.nlm.nih.gov/pubmed/24861055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.91 |
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