Epigenetic Manipulation Restores Functions of Defective CD8(+) T Cells From Chronic Viral Infection

Functional exhaustion of antigen-specific T cells is a defining characteristic of many chronic infections, but the underlying mechanisms of T cell dysfunction are not well understood. Epigenetics plays an important role in the control of T cell development, differentiation, and function. To examine...

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Udgivet i:Mol Ther
Main Authors: Zhang, Fuqin, Zhou, Xiaohui, DiSpirito, Joanna R, Wang, Chuan, Wang, Ying, Shen, Hao
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4435497/
https://ncbi.nlm.nih.gov/pubmed/24861055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.91
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