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Diabetes-associated dysregulation of O-GlcNAcylation in rat cardiac mitochondria

Elevated mitochondrial O-GlcNAcylation caused by hyperglycemia, as occurs in diabetes, significantly contributes to mitochondrial dysfunction and to diabetic cardiomyopathy. However, little is known about the enzymology of mitochondrial O-GlcNAcylation. Herein, we investigated the enzymes responsibl...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Banerjee, Partha S., Ma, Junfeng, Hart, Gerald W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434690/
https://ncbi.nlm.nih.gov/pubmed/25918408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424017112
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