Oxygen modulates prostacyclin synthesis in ovine fetal pulmonary arteries by an effect on cyclooxygenase.

Prostacyclin (PGI2) plays an integral role in O2 mediation of pulmonary vasomotor tone in the fetus and newborn. We hypothesized that O2 modulates PGI2 synthesis in vitro in ovine fetal intrapulmonary arteries, with decreasing O2 causing attenuated synthesis. A decline in PO2 from 680 to 40 mmHg cau...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Shaul, P W, Campbell, W B, Farrar, M A, Magness, R R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1992
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443365/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1334969/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116100
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