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GATA-1 Deficiency Rescues Trabecular but not Cortical Bone in OPG Deficient Mice
GATA-1(low/low) mice have an increase in megakaryocytes (MKs) and trabecular bone. The latter is thought to result from MKs directly stimulating osteoblastic bone formation while simultaneously inhibiting osteoclastogenesis. Osteoprotegerin (OPG) is known to inhibit osteoclastogenesis and OPG(−/−) m...
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| Publicado no: | J Cell Physiol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4433552/ https://ncbi.nlm.nih.gov/pubmed/25205203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24803 |
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