Perampanel efficacy and tolerability with enzyme-inducing AEDs in patients with epilepsy

OBJECTIVE: Evaluate the impact of concomitant enzyme (CYP3A4)-inducer antiepileptic drugs (EIAEDs) on the efficacy and safety of perampanel in patients from the 3 phase-III clinical trials. METHODS: Patients with pharmacoresistant partial-onset seizures in the 3 phase-III clinical studies were aged...

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Veröffentlicht in:Neurology
Hauptverfasser: Gidal, Barry E., Laurenza, Antonio, Hussein, Ziad, Yang, Haichen, Fain, Randi, Edelstein, Jacob, Kumar, Dinesh, Ferry, Jim
Format: Artigo
Sprache:Inglês
Veröffentlicht: Lippincott Williams & Wilkins 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433458/
https://ncbi.nlm.nih.gov/pubmed/25878177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000001558
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