Restricted immunoglobulin VH usage and VDJ combinations in the human response to Haemophilus influenzae type b capsular polysaccharide. Nucleotide sequences of monospecific anti-Haemophilus antibodies and polyspecific antibodies cross-reacting with self antigens.

To examine the human antibody repertoire generated against a biologically significant antigen we have obtained sequences of heavy chain variable region genes (IgVH) from 15 monoclonal antibodies specific for the capsular polysaccharide of Haemophilus influenzae type b (Hib PS). All VH segments are m...

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Библиографические подробности
Опубликовано в: :J Clin Invest
Главные авторы: Adderson, E E, Shackelford, P G, Quinn, A, Wilson, P M, Cunningham, M W, Insel, R A, Carroll, W L
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 1993
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443339/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8514881/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116514
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