AMA1-Deficient Toxoplasma gondii Parasites Transiently Colonize Mice and Trigger an Innate Immune Response That Leads to Long-Lasting Protective Immunity

The apical membrane antigen 1 (AMA1) protein was believed to be essential for the perpetuation of two Apicomplexa parasite genera, Plasmodium and Toxoplasma, until we genetically engineered viable parasites lacking AMA1. The reduction in invasiveness of the Toxoplasma gondii RH-AMA1 knockout (RH-AMA...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Lagal, Vanessa, Dinis, Márcia, Cannella, Dominique, Bargieri, Daniel, Gonzalez, Virginie, Andenmatten, Nicole, Meissner, Markus, Tardieux, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432741/
https://ncbi.nlm.nih.gov/pubmed/25847964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02606-14
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