Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol

BACKGROUND: Na/K-ATPase (NKA) is inhibited by perillyl alcohol (POH), a monoterpene used in the treatment of tumors, including brain tumors. The NKA α(1) subunit is known to be superexpressed in glioblastoma cells (GBM). This isoform is embedded in caveolar structures and is probably responsible for...

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Veröffentlicht in:Mol Cancer
Hauptverfasser: Garcia, Diogo Gomes, Castro-Faria-Neto, Hugo Caire de, Silva, Camila Ignácio da, Souza e Souza, Kauê Francisco Correa de, Gonçalves-de-Albuquerque, Cassiano Felippe, Silva, Adriana Ribeiro, Amorim, Lidia Maria da Fonte de, Freire, Aline Soares, Santelli, Ricardo Erthal, Diniz, Luan Pereira, Gomes, Flávia Carvalho Alcantara, Faria, Mauro Velho de Castro, Burth, Patrícia
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432499/
https://ncbi.nlm.nih.gov/pubmed/25976744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0374-5
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