New insights on the mechanism(s) of the dominant negative effect of mutant thyroid hormone receptor in generalized resistance to thyroid hormone.

Generalized resistance to thyroid hormone (GRTH) is a syndrome of hyposensitivity to triiodothyronine (T3) that displays autosomal dominant inheritance. The genetic defect commonly lies in the ligand-binding domain of one of the TR beta alleles. Since there are two major thyroid hormone receptor (TR...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Yen, P M, Sugawara, A, Refetoff, S, Chin, W W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443242/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1430208/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116058
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