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Reduced Ssy1-Ptr3-Ssy5 (SPS) Signaling Extends Replicative Life Span by Enhancing NAD(+) Homeostasis in Saccharomyces cerevisiae

Attenuated nutrient signaling extends the life span in yeast and higher eukaryotes; however, the mechanisms are not completely understood. Here we identify the Ssy1-Ptr3-Ssy5 (SPS) amino acid sensing pathway as a novel longevity factor. A null mutation of SSY5 (ssy5Δ) increases replicative life span...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Tsang, Felicia, James, Christol, Kato, Michiko, Myers, Victoria, Ilyas, Irtqa, Tsang, Matthew, Lin, Su-Ju
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432292/
https://ncbi.nlm.nih.gov/pubmed/25825491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.644534
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