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Induction of Heme Oxygenase-1 by Na(+)-H(+) Exchanger 1 Protein Plays a Crucial Role in Imatinib-resistant Chronic Myeloid Leukemia Cells

Resistance toward imatinib (IM) and other BCR/ABL tyrosine kinase inhibitors remains troublesome in the treatment of advanced stage chronic myeloid leukemia (CML). The aim of this study was to estimate the reversal effects of down-regulation of Na(+)/H(+) exchanger 1 (NHE1) on the chemoresistance of...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ma, Dan, Fang, Qin, Wang, Ping, Gao, Rui, Wu, Weibing, Lu, Tangsheng, Cao, Lu, Hu, Xiuying, Wang, Jishi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432277/
https://ncbi.nlm.nih.gov/pubmed/25802333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.626960
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