Influence of ABCC2 and ABCC4 Polymorphisms on Tenofovir Plasma Concentrations in Thai HIV-Infected Patients

Tenofovir (TFV) is eliminated by renal excretion, which is mediated through multidrug-resistant protein 2 (MRP2) and MRP4, encoded by ABCC2 and ABCC4, respectively. Genetic polymorphisms of these transporters may affect the plasma concentrations of tenofovir. Therefore, the aim of this study was to...

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Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Rungtivasuwan, Kanokrat, Avihingsanon, Anchalee, Thammajaruk, Narukjaporn, Mitruk, Siwaporn, Burger, David M., Ruxrungtham, Kiat, Punyawudho, Baralee, Pengsuparp, Thitima
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2015
Предметы:
Pharmacology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432150/
https://ncbi.nlm.nih.gov/pubmed/25801567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04930-14
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