Inhibition and Reversal of Microbial Attachment by an Antibody with Parasteric Activity against the FimH Adhesin of Uropathogenic E. coli

Attachment proteins from the surface of eukaryotic cells, bacteria and viruses are critical receptors in cell adhesion or signaling and are primary targets for the development of vaccines and therapeutic antibodies. It is proposed that the ligand-binding pocket in receptor proteins can shift between...

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Publicado en:PLoS Pathog
Main Authors: Kisiela, Dagmara I., Avagyan, Hovhannes, Friend, Della, Jalan, Aachal, Gupta, Shivani, Interlandi, Gianluca, Liu, Yan, Tchesnokova, Veronika, Rodriguez, Victoria B., Sumida, John P., Strong, Roland K., Wu, Xue-Ru, Thomas, Wendy E., Sokurenko, Evgeni V.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431754/
https://ncbi.nlm.nih.gov/pubmed/25974133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004857
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